Year 2020 (54)

Edition nr. 2

Genotyping prior to clopidogrel treatment?

Clopidogrel, which is used as a platelet aggregation inhibitor for the prophylaxis of atherothrombotic complications, is enzymatically activated by the enzyme CYP2C19. Patients whose genetic predisposition prevents or reduces the production of th ...

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Drug interactions with CYP enzymes

Cytochrome P450 enzymes (CYP enzymes) are involved in the metabolism of many drugs. Since the activity of CYP enzymes can be inhibited or stimulated by other drugs, a large variety of interactions can occur. Whereas many of these interactions are ...

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