The Excedrin website is merely a long advertisement, offering little added value to consumers. Although the drug may have been developed to treat migraine, the combination of acetylsalicylic acid, paracetamol and caffeine in these quantities is definitely not effective for this purpose. The dosages used are rather low. It is a case of nothing new. Combination formulas are generally not the preferred option, as the individual agents should be tried first to control the symptoms. In addition, it is undesirable to provide large doses of a platelet aggregation inhibitor as self-medication, in view of the many interactions. The maximum dosage of paracetamol is needlessly limited to 1500 mg a day in this product. A combination of paracetamol/caffeine (500/50 mg) in normal dosages (up to 8 tablets a day) is a much better combination and dosage for patients with migraine. In addition, the proprietary product is more than twice as expensive as the generic product. In conclusion, there is no reason for patients to start using the ‘new’ drug Excedrin. Patients can find non-sponsored information about migraine at www.thuisarts.nl and www.apotheek.nl.


  1. Productinformatie Excedrin®, via: www.cbg-meb.nl, Geneesmiddeleninformatiebank.
  2. Productinformatie APC Apotex, via: www.cbg-meb.nl, Geneesmiddeleninformatiebank.
  3. Informatorium Medicamentorum. Den Haag: KNMP, 2015.
  4. Goldstein J, et al. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 2006; 46: 444-453.
  5. Goldstein J, et al. Results of a multicenter, double-blind, randomized, parallel-group, placebo-controlled, single-dose study comparing the fixed combination of acetaminophen, acetylsalicylic acid, and caffeine with ibuprofen for acute treatment of patients with severe migraine. Cephalalgia 2014; 34: 1070-1078.

*The literature refers to the Dutch text


  • mw drs M.A.E. Nieuwhof