In short Article

New product form: Calcipotriol/betamethasone aerosol foam for psoriasis

Enstilar® (Leo Pharma, Denmark), aerosol foam for cutaneous use


Calcipotriol/betamethasone aerosol foam 0.05mg/g and 0.5 mg/g (Enstilar®) were registered in 2016 for the ‘local treatment of psoriasis vulgaris in adults’. The combination of calcipotriol and betamethasone has been in use for many years in primary care as an ointment or gel for the treatment of mild forms of psoriasis. Research has shown that the aerosol foam works better than the ointment and gel, though the differences are small. It is unclear whether these differences are clinically relevant. A striking aspect is that Enstilar® came on the market at the same moment at which the patent for proprietary calcipotriol/betamethasone ointment ran out and a generic ointment became available.

  • Research has shown that calcipotriol/betamethasone aerosol foam works better than calcipotriol/betamethasone ointment or gel.
  • The differences bwteen the aerosol foam and the ointment/gel are small, and the foam is more expensive. It is questionable whether this difference in effectiveness, of unclear clinical relevance, justifies the higher costs.
  • The manufacturer has reported that the aerosol foam is easier to use for patients, but there is no research evidence to prove this claim.
  • In view of the minor difference in effectiveness and the unclear clinical relevance, the drug rating for this agent is ‘+/-’.

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*The literature refers to the Dutch text

Authors

  • dr L.M.L. Stolk