In short Article

Lower target values for cholesterol after cerebral infarction or TIA


Just like patients with cardiovascular problems, patients who have had a cerebral infarction or TIA are advised to aim for LDL-cholesterol values below 1.8 mmol/L. At the time when this recommendation was published, there had been insufficient research to substantiate this advice for this target group. A new study offers some substantiation, but is subject to various limitations.

  • New research finds a lower risk for a composite endpoint of cardiovascular complications at lower target values for LDL-cholesterol, but this study has too many limitations to enable a firm conclusion to be drawn from the findings.
  • Previous research shows that statins are only moderately effective in secondary prevention after a TIA or cerebral infarction.
  • There is insufficient evidence for a lower target value for LDL-cholesterol in secondary prevention for patients with a history of TIA or cerebral infarction.

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Authors

  • Anton J.F.A. Kerst, dr
  • Frans M. Helmerhorst, prof. dr
  • Marielle A.E. Nieuwhof, pharmacist