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Living systematic reviews


Systematic reviews and meta-analyses (including network meta-analyses) are increasingly being updated and are evolving into ‘living systematic reviews’ (LSRs). As a result of rapid developments in medical science and current pharmacotherapeutic issues, the ‘survival time’ of systematic reviews is limited. Unlike conventional systematic reviews, living systematic reviews are updated more frequently, according to a predefined schedule. Methods and quality requirements for their design are largely identical. Living systematic reviews are essential for the formulation and updating of guidelines.

  • Rapid developments in drugs mean that the period during which systematic reviews and meta-analyses (including network meta-analyses) remain useful is limited. 
  • One solution is that of living systematic reviews and meta-analyses, which are frequently updated, in a predefined schedule.
  • Like traditional systematic reviews, living systematic reviews must meet established quality requirements. 
  • Guidelines should preferably be based on living systematic reviews, enabling any gaps to be filled as soon as possible.

  1. Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med. 2010 Sep 21;7(9):e1000326. doi: 10.1371/journal.pmed.1000326.
  2. Shojania KG, Sampson M, Ansari MT, Ji J, Doucette S, Moher D. How quickly do systematic reviews go out of date? A survival analysis. Ann Intern Med. 2007 Aug 21;147(4):224-33. doi: 10.7326/0003-4819-147-4-200708210-00179.
  3. Elliott JH, Turner T, Clavisi O, Thomas J, Higgins JP, Mavergames C, et al. Living systematic reviews: an emerging opportunity to narrow the evidence-practice gap. PLoS Med. 2014 Feb 18;11(2):e1001603. doi: 10.1371/journal.pmed.1001603.
  4. Martínez García L, Sanabria AJ, García Alvarez E, Trujillo-Martín MM, Etxeandia-Ikobaltzeta I, Kotzeva A, et al. Updating Guidelines Working Group. The validity of recommendations from clinical guidelines: a survival analysis. CMAJ. 2014 Nov 4;186(16):1211-9. doi: 10.1503/cmaj.140547. Erratum in: CMAJ. 2017 Jan 9;189(1):E33. 
  5. Garner P, Hopewell S, Chandler J, MacLehose H, Schünemann HJ, Akl EA, et al. Panel for updating guidance for systematic reviews (PUGs). When and how to update systematic reviews: consensus and checklist. BMJ. 2016 Jul 20;354:i3507. doi: 10.1136/bmj.i3507. Erratum in: BMJ. 2016 Sep 06;354:i4853. 
  6. This chapter should be cited as: Cumpston M, Chandler J. Chapter IV: Updating a review. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021. Available from: www.training.cochrane.org/handbook. Accessed 13-07-2021
  7. Elliott JH, Synnot A, Turner T, Simmonds M, Akl EA, McDonald S, et al. Living Systematic Review Network. Living systematic review: 1. Introduction-the why, what, when, and how. J Clin Epidemiol. 2017 Nov;91:23-30. doi: 10.1016/j.jclinepi.2017.08.010. 
  8. Available from: https://pubmed.ncbi.nlm.nih.gov/?term=living+systematic+reviews. Accessed 19-09-2021
  9. Brooker J, Synnot A, McDonald S et al. Guidance for the production and publication of Cochrane living systematic reviews: Cochrane Reviews in living mode. 2019. Available from: https://community.cochrane.org/sites/default/files/uploads/inline-files/Transform/201912_LSR_Revised_Guidance.pdf. Accessed 17-07-2021
  10. Stolk LM. Netwerk meta-analyse van geneesmiddelen. Gebu. 2020;54(8):89-95.
  11. Dekkers OM. Meta-analyse: mogelijkheden en beperkingen. Gebu. 2012;46(8):85-92.
  12. Simmonds M, Salanti G, McKenzie J, Elliott J; Living Systematic Review Network. Living systematic reviews: 3. Statistical methods for updating meta-analyses. J Clin Epidemiol. 2017 Nov;91:38-46. doi: 10.1016/j.jclinepi.2017.08.008.
  13. Thomas J, Noel-Storr A, Marshall I, Wallace B, McDonald S, Mavergames C, et al. Living Systematic Review Network. Living systematic reviews: 2. Combining human and machine effort. J Clin Epidemiol. 2017 Nov;91:31-37. doi: 10.1016/j.jclinepi.2017.08.011.
  14. Maslove DM. Medical Preprints-A Debate Worth Having. JAMA. 2018 Feb 6;319(5):443-444. doi: 10.1001/jama.2017.17566. 
  15. van Schalkwyk MCI, Hird TR, Maani N, Petticrew M, Gilmore AB. The perils of preprints. BMJ. 2020 Aug 17;370:m3111. doi: 10.1136/bmj.m3111. 
  16. LSRs and LSR Protocols on Cochrane Library. Available from: https://community.cochrane.org/review-production/production-resources/living-systematic-reviews/lsrs-and-lsr-protocols-cochrane-library. Accessed 23-07-2021
  17. Sbidian E, Chaimani A, Garcia-Doval I, Doney L, Dressler C, Hua C, et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4. Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011535.pub4/full
  18. Macdonald H, Loder E, Abbasi K. Living systematic reviews at The BMJ. BMJ. 2020 Jul 30;370:m2925. doi: 10.1136/bmj.m2925.
  19. Siemieniuk RA, Bartoszko JJ, Ge L, Zeraatkar D, Izcovich A, Kum E, et al. Drug treatments for covid-19: living systematic review and network meta-analysis. BMJ. 2020 Jul 30;370:m2980. doi: 10.1136/bmj.m2980. Update in: BMJ. 2020 Sep 11;370:m3536. Update in: BMJ. 2020 Dec 17;371:m4852. Update in: BMJ. 2021 Mar 31;372:n858. Erratum in: BMJ. 2021 Apr 13;373:n967. Available from: https://www.bmj.com/content/370/bmj.m2980
  20. Korang SK, Juul S, Nielsen EE, Feinberg J, Siddiqui F, Ong G, et al. Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project). Syst Rev. 2020 Nov 20;9(1):262. doi: 10.1186/s13643-020-01516-1. 
  21. Higgins J TJ, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane handbook for systematic reviews of interventions version 6.0. (updated July 2019). Available from: https://training.cochrane.org/handbook/archive/v6.
  22. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015 Jan 1;4(1):1. doi: 10.1186/2046-4053-4-1.
  23. PROSPERO International prosepective register of systematic reviews. Available from: https://www.crd.york.ac.uk/prospero/. Accessed 24-07-2021

The literature refers to the Dutch text.

Authors

  • Leo M.L. Stolk, dr
  • Rutger A. Middelburg