Several studies have examined the efficacy and adverse effects of amisulpride for patients with schizophrenia, and these studies have been included in several meta-analyses (including network meta-analyses). The results show that amisulpride considerably reduces the characteristic symptoms of schizophrenia. However, the differences with other antipsychotics are small. The findings also show that significantly fewer people discontinue the treatment with amisulpride because of adverse effects or lack of effect than with placebo and most other antipsychotics. The adverse effects profile appears to be mild. Although the studies into amisulpride have some shortcomings, it appears that amisulpride for the treatment of schizophrenia is effective and has a mild adverse effects profile. The currently available studies do not, however, allow an unequivocal conclusion to be drawn. Ge-Bu therefore gives this drug a rating of +/-.
Pill verdict: +/- moderate
- The various antipsychotics (except clozapine) have comparable efficacy and effectivity, but differ considerably as regards their adverse effects.
- Studies of amilsulpride, which has been around for a long time but has only recently been authorised in the Netherlands, have shown it to be efficacious and effective and having a mild adverse effects profile, but the quality of the studies is open to criticism.
- Amisulpride is currently 2.5 to 100 times as expensive as other antipsychotics, which is a reason to regard it as a drug of second choice.
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